Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio, and Alyftrek for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease, and Journavx, a non-opioid pain medication approved for the treatment of moderate-to-severe acute pain in adults. Additionally, Vertex is evaluating small-molecule inhibitors of APOL1-mediated kidney diseases. Vertex is also investigating cell therapies to deliver a potential functional cure for type 1 diabetes.
The chart shows the growth of an initial investment of $10,000 in Vertex Pharmaceuticals Inc, comparing it to the performance of the S&P 500 index. All prices have been adjusted for splits and dividends.
Returns By Period
Vertex Pharmaceuticals Inc (VRTX) has returned -3.44% so far this year and -5.84% over the past 12 months. Looking at the last ten years, VRTX has achieved an annualized return of 18.58%, outperforming the Benchmark (SPY), which averaged 12.23% per year.
VRTX
1M-7.96%
6M8.41%
YTD-3.44%
1Y-5.84%
5Y15.58%
10Y18.58%
Benchmark (SPY)
1M-3.85%
6M-2.35%
YTD-4.36%
1Y34.06%
5Y9.80%
10Y12.23%
Monthly Returns
The table below presents the monthly returns of Vertex Pharmaceuticals Inc (VRTX) with color gradation from worst to best to easily spot seasonal factors.
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
2026
3.42%
6.44%
-10.08%
-2.33%
2025
14.52%
3.55%
1.46%
4.78%
-12.81%
0.89%
2.55%
-14.51%
0.16%
8.12%
1.20%
4.96%
2024
7.01%
-3.06%
-1.23%
-6.57%
15.92%
3.02%
5.94%
0.01%
-5.60%
0.84%
-0.62%
-13.86%
2023
11.95%
-9.71%
9.00%
8.17%
-4.89%
8.46%
1.02%
-0.88%
-1.30%
4.43%
-2.78%
14.58%
2022
11.30%
-5.10%
13.87%
4.46%
1.70%
2.35%
0.09%
0.70%
2.80%
6.23%
1.27%
-9.35%
2021
-3.71%
-7.99%
1.04%
1.07%
-3.98%
-3.75%
0.16%
-0.18%
-9.59%
2.65%
1.50%
12.28%
2020
3.09%
-2.92%
6.02%
8.22%
15.53%
1.71%
-6.37%
1.79%
-2.07%
-23.65%
7.87%
3.90%
2019
18.42%
-1.14%
-3.16%
-8.76%
-1.53%
9.89%
-9.97%
3.81%
-6.16%
15.50%
13.00%
-1.80%
2018
11.25%
-4.64%
-1.63%
-5.18%
0.56%
9.75%
3.95%
5.22%
5.19%
-12.31%
6.65%
-9.25%
2017
15.37%
5.40%
19.12%
8.52%
3.88%
3.93%
17.24%
4.91%
-5.42%
-3.31%
-2.08%
4.73%
2016
6.73%
10.58%
-7.41%
13.23%
-2.88%
-8.23%
-12.26%
8.68%
-9.99%
Performance Indicators
The charts below present risk-adjusted performance metrics for Vertex Pharmaceuticals Inc (VRTX) and compare them to a Benchmark (SPY). These indicators evaluate an investment's returns against its associated risks.
Sharpe ratio
Sortino ratio
Omega ratio
Calmar ratio
Martin ratio
sharpe ratio
The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.
These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns.
The chart below shows the rolling Sharpe ratio of VRTX compared to the benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.
Volatility Chart
The current Vertex Pharmaceuticals Inc volatility is 2.55%, representing the standart deviation of percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. It shows the maximum percentage drop from a peak to a trough over a specified period, indicating the risk of significant losses. Although chart shows positive values, it represents the percentage drop from the peak, so a value of 10% means the portfolio has dropped 10% from its highest point.
Income Statement
The income statement provides a summary of a company's revenues, expenses, and profits over a specific period. It shows how much money the company earned (revenues) and how much it spent (expenses), leading to the net income or profit. This statement is crucial for understanding a company's financial performance and profitability.
2025
2024
2023
2022
2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
Liabilities And Equity (USD)
25.64B
22.53B
22.73B
18.15B
13.43B
11.75B
8.32B
6.25B
3.55B
2.90B
2.50B
2.33B
2.32B
2.76B
2.20B
Temporary Equity (USD)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Equity Attributable To Parent (USD)
18.67B
16.41B
17.58B
13.91B
10.10B
8.69B
6.09B
4.44B
2.03B
1.16B
939.97M
1.08B
1.36B
999.18M
786.84M
Equity Attributable To Noncontrolling Interest (USD)
Vertex Pharmaceuticals has underperformed the broader market over the past 12 months, but the biotech company shows signs of a potential rebound. With its core cystic fibrosis franchise continuing to drive growth and several promising pipeline candidates approaching regulatory approval—including povetacicept for kidney disease, inaxaplin for APOL-1-mediated kidney disease, and zimislecel for Type 1 diabetes—the company's long-term prospects appear strong, making it a potential buying opportunity.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Despite recent underperformance (down 10% over 12 months), the company demonstrates strong fundamentals with growing CF franchise revenue, expanding non-CF portfolio generating $500M+, and multiple promising pipeline candidates approaching regulatory approval within the next year. The article positions the current dip as a buying opportunity with strong long-term growth prospects.
Avaí Bio announced a critical milestone in creating a Master Cell Bank of genetically modified cells that overexpress the α-Klotho protein, an anti-aging protein that declines by 50% after age 40. The company is partnering with Austrianova to use Cell-in-a-Box encapsulation technology for its Klothonova anti-aging and Insulinova diabetes programs. This development occurs as the cell and gene therapy market expands rapidly, with the sector forecast to grow from $10.4 billion to over $45 billion by 2035.
Benzinga•Equity-Insider.Com
AI Insight
Company demonstrated successful scale with Casgevy, the world's first approved CRISPR-based treatment, and is expanding regulatory submissions for younger age groups, showcasing leadership in cell and gene therapy commercialization.
CRISPR Therapeutics stock has declined 9% this year following a $585.2 million convertible notes offering. While the company has an approved gene-editing therapy (Casgevy) and strong financial reserves of $1.8 billion, it remains deeply unprofitable with a net loss of $581.6 million and minimal revenue of $3.5 million. The analyst suggests it may be worth considering as a mid-cap growth stock with potential upside, though not a bargain due to inherent risks.
The Motley Fool•David Jagielski, Cpa
AI Insight
Vertex is mentioned as CRISPR's development partner for Casgevy, sharing in profits. While this partnership provides revenue potential, the article provides limited information about Vertex's independent performance or outlook.
The article recommends three pharmaceutical stocks as attractive long-term holdings: Eli Lilly, which dominates the growing chronic weight management market with its blockbuster drug tirzepatide; Vertex Pharmaceuticals, which maintains a monopoly in cystic fibrosis treatments while expanding into other therapeutic areas; and Pfizer, which despite recent underperformance, offers undervalued shares, a strong pipeline, and an attractive 6.3% dividend yield.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Dominates the cystic fibrosis market with a monopoly on genetic-targeting treatments, generating consistent revenue and earnings. Growing CF patient population and expanding beyond CF into acute pain and blood disorders with strong phase 3 results position the company well for medium to long-term performance.
Eli Lilly and Vertex Pharmaceuticals are both prominent drugmakers with strong track records, but Eli Lilly emerges as the better growth stock choice. Eli Lilly leads the rapidly growing weight-loss market with Zepbound and has a strong pipeline including orforglipron and retatrutide, plus newer approvals in Alzheimer's and eczema treatments. Vertex Pharmaceuticals has a solid cystic fibrosis franchise and is expanding into sickle cell disease, acute pain, and kidney disease treatments. However, Eli Lilly generates higher revenue and net income with faster growth, and both companies have similar valuations, giving Eli Lilly the edge.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Strong core cystic fibrosis franchise with exclusive market position; successful expansion into new areas with approvals for Casgevy (sickle cell disease) and Journavx (acute pain); promising pipeline including povetacicept for kidney disease and zimislecel for Type 1 diabetes; potential for long-term growth beyond CF business. However, rated slightly lower than Eli Lilly due to slower growth metrics and similar valuation without a significant discount.
The 2026 UNCF 'A Mind Is...' New England Gala raised a record-breaking $800,000 to support historically Black colleges and universities and provide scholarships to students. The event honored Demond Martin, Governor Charlie Baker, and Pamela Everhart for their contributions to educational equity and community development.
GlobeNewswire Inc.•Uncf
AI Insight
Listed as a bronze sponsor supporting historically Black colleges and universities
Vertex Pharmaceuticals, a biotech leader in cystic fibrosis treatment, is expanding into new therapeutic areas with recent approvals for Casgevy (blood disorders) and Journavx (non-opioid pain). The company's kidney disease candidate povetacicept is expected to be submitted for regulatory review by month-end. With $12 billion in annual sales and non-CF drugs projected to generate $500 million this year, analysts suggest the stock trading at $480 could reach $600 (25% gain) if new drug revenues perform strongly and pipeline advancements continue.
The Motley Fool•Adria Cimino
AI Insight
The company demonstrates strong market leadership in cystic fibrosis with $12 billion in annual sales, successful expansion into new therapeutic areas (blood disorders, pain management), promising pipeline candidate (povetacicpoint) approaching regulatory submission, and projected $500 million revenue from newer drugs this year. The analyst suggests a realistic 25% upside to $600 based on continued execution and market expansion.
U.S. stocks rallied Tuesday as crude oil plummeted 10% to $85/barrel following President Trump's signals that the Iran conflict may be ending soon and his commitment to keep the Strait of Hormuz safe. The S&P 500 rose 0.3%, Dow gained 0.4%, and Nasdaq 100 advanced 0.5%, while the VIX dropped 9.3% signaling reduced market fear.
Benzinga•Piero Cingari
AI Insight
Stock gained 8.4% on the day, among the top gainers in the Russell 1000.
Vertex Pharmaceuticals shares surged 6.32% in premarket trading after announcing positive Phase 3 RAINIER trial results for its kidney drug povetacicept. The trial met its primary objective with a 52% reduction in urine protein and 49.8% reduction versus placebo. An analyst upgraded the probability of success to 90% ahead of expected FDA approval by year-end.
Benzinga•Vandana Singh
AI Insight
Positive Phase 3 trial results showing significant efficacy in reducing urine protein and hematuria. Analyst upgraded probability of success to 90%, FDA rolling review granted, and potential approval expected by year-end. Stock up 6.32% in premarket trading.
The article recommends two biotech companies as strong portfolio additions in 2026. Regeneron Pharmaceuticals is highlighted for its blockbuster drugs Dupixent and Eylea HD showing strong sales growth, along with a rich pipeline in multiple therapeutic areas, trading at a reasonable 17x forward earnings. Vertex Pharmaceuticals is praised as the leading cystic fibrosis treatment player with strong intellectual property protection and recent expansion into gene-editing and pain management, trading at 24x forward earnings.
The Motley Fool•Adria Cimino
AI Insight
Dominant market position in cystic fibrosis with drugs treating 90% of CF patients, strong intellectual property protection through the next decade, recent approvals in gene-editing and pain management expanding revenue potential, and reasonable valuation at 24x forward earnings.