Vertex Pharmaceuticals Inc logo

Vertex Pharmaceuticals Inc (VRTX)

Common Stock · Currency in USD · XNAS

Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio, and Alyftrek for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease, and Journavx, a non-opioid pain medication approved for the treatment of moderate-to-severe acute pain in adults. Additionally, Vertex is evaluating small-molecule inhibitors of APOL1-mediated kidney diseases. Vertex is also investigating cell therapies to deliver a potential functional cure for type 1 diabetes.

Company Info

SIC2834
Composite FIGIBBG000C1S2X2
CIK0000875320
IPOJul 31, 1991
Sectorpharmaceutical preparations

Highlights

Market Cap$111.45B
EPS$16.96
P/E Ratio25.73
Revenue$12.08B
Gross Profit$10.65B
Net Income$4.33B
Employees6,400
WSO254,034,190
Phone(617) 341-6393

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Analysis

Share Price Chart

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Vertex Pharmaceuticals Inc, comparing it to the performance of the S&P 500 index.
All prices have been adjusted for splits and dividends.

Returns By Period

Vertex Pharmaceuticals Inc (VRTX) has returned -3.44% so far this year and -5.84% over the past 12 months. Looking at the last ten years, VRTX has achieved an annualized return of 18.58%, outperforming the Benchmark (SPY), which averaged 12.23% per year.

VRTX

1M-7.96%
6M8.41%
YTD-3.44%
1Y-5.84%
5Y15.58%
10Y18.58%

Benchmark (SPY)

1M-3.85%
6M-2.35%
YTD-4.36%
1Y34.06%
5Y9.80%
10Y12.23%

Monthly Returns

The table below presents the monthly returns of Vertex Pharmaceuticals Inc (VRTX) with color gradation from worst to best to easily spot seasonal factors.

JanFebMarAprMayJunJulAugSepOctNovDec
20263.42%6.44%-10.08%-2.33%
202514.52%3.55%1.46%4.78%-12.81%0.89%2.55%-14.51%0.16%8.12%1.20%4.96%
20247.01%-3.06%-1.23%-6.57%15.92%3.02%5.94%0.01%-5.60%0.84%-0.62%-13.86%
202311.95%-9.71%9.00%8.17%-4.89%8.46%1.02%-0.88%-1.30%4.43%-2.78%14.58%
202211.30%-5.10%13.87%4.46%1.70%2.35%0.09%0.70%2.80%6.23%1.27%-9.35%
2021-3.71%-7.99%1.04%1.07%-3.98%-3.75%0.16%-0.18%-9.59%2.65%1.50%12.28%
20203.09%-2.92%6.02%8.22%15.53%1.71%-6.37%1.79%-2.07%-23.65%7.87%3.90%
201918.42%-1.14%-3.16%-8.76%-1.53%9.89%-9.97%3.81%-6.16%15.50%13.00%-1.80%
201811.25%-4.64%-1.63%-5.18%0.56%9.75%3.95%5.22%5.19%-12.31%6.65%-9.25%
201715.37%5.40%19.12%8.52%3.88%3.93%17.24%4.91%-5.42%-3.31%-2.08%4.73%
20166.73%10.58%-7.41%13.23%-2.88%-8.23%-12.26%8.68%-9.99%

Performance Indicators

The charts below present risk-adjusted performance metrics for Vertex Pharmaceuticals Inc (VRTX) and compare them to a Benchmark (SPY). These indicators evaluate an investment's returns against its associated risks.

Sharpe ratio

-2.00-1.000.001.002.003.00VRTX: -0.09SPY: 0.92

Sortino ratio

-6.00-4.00-2.000.002.004.00VRTX: -0.11SPY: 1.40

Omega ratio

0.501.001.502.00VRTX: 0.98SPY: 1.22

Calmar ratio

0.002.004.006.00VRTX: -0.31SPY: 1.20

Martin ratio

0.001.003.00VRTX: -0.01SPY: 0.42

The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns.

The chart below shows the rolling Sharpe ratio of VRTX compared to the benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.

Volatility Chart

The current Vertex Pharmaceuticals Inc volatility is 2.55%, representing the standart deviation of percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. It shows the maximum percentage drop from a peak to a trough over a specified period, indicating the risk of significant losses.
Although chart shows positive values, it represents the percentage drop from the peak, so a value of 10% means the portfolio has dropped 10% from its highest point.

Income Statement

The income statement provides a summary of a company's revenues, expenses, and profits over a specific period. It shows how much money the company earned (revenues) and how much it spent (expenses), leading to the net income or profit. This statement is crucial for understanding a company's financial performance and profitability.

202520242023202220212020201920182017201620152014201320122011
Liabilities And Equity (USD)25.64B22.53B22.73B18.15B13.43B11.75B8.32B6.25B3.55B2.90B2.50B2.33B2.32B2.76B2.20B
Temporary Equity (USD)---------------
Equity Attributable To Parent (USD)18.67B16.41B17.58B13.91B10.10B8.69B6.09B4.44B2.03B1.16B939.97M1.08B1.36B999.18M786.84M
Equity Attributable To Noncontrolling Interest (USD)--------13.73M181.61M153.66M21.18M-196.67M141.63M
Equity (USD)18.67B16.41B17.58B13.91B10.10B8.69B6.09B4.44B2.04B1.34B1.09B1.10B1.36B1.20B928.48M
Redeemable Noncontrolling Interest, Preferred (USD)---------------
Redeemable Noncontrolling Interest (USD)---------------
Commitments and Contingencies (USD)---------------
Noncurrent Liabilities (USD)3.12B2.56B1.60B1.50B1.19B1.19B898.39M690.40M696.45M766.06M898.90M870.24M564.81M1.09B846.42M
Other Current Liabilities (USD)3.00B2.80B2.89B2.19B1.76B1.55B1.09B884.55M620.24M644.70M343.53M205.89M271.72M269.19M260.25M
Wages (USD)397.70M352.10M295.00M246.50M191.30M169.39M159.46M124.75M113.03M86.39M87.87M91.18M76.79M62.14M57.45M
Accounts Payable (USD)461.70M413.00M364.90M303.90M195.00M155.14M87.61M110.99M73.99M61.45M74.94M71.19M49.33M101.29M74.64M
Current Liabilities (USD)3.86B3.56B3.55B2.74B2.14B1.88B1.33B1.12B807.26M792.54M506.35M368.25M397.83M432.62M392.35M
Liabilities (USD)6.98B6.12B5.15B4.24B3.33B3.06B2.23B1.81B1.50B1.56B1.41B1.24B962.64M1.52B1.24B
Other Non-current Assets (USD)14.02B12.11B7.75B4.31B3.47B3.22B3.10B1.59B107.61M366.89M394.01M72.36M33.55M736.09M739.85M
Intangible Assets (USD)424.20M825.90M839.90M603.60M400.00M400.00M400.00M--------
Fixed Assets (USD)-------812.01M789.44M698.36M697.72M715.81M696.91M433.61M133.18M
Noncurrent Assets (USD)14.44B12.94B8.59B4.92B3.87B3.62B3.50B2.40B897.05M1.07B1.09B788.17M730.47M1.17B873.03M
Other Current Assets (USD)9.41B8.29B13.30B12.66B9.21B7.85B4.66B3.64B2.47B1.72B1.33B1.50B1.57B1.56B1.22B
Prepaid Expenses (USD)101.70M102.20M108.60M111.80M---74.05M62.48M36.13M22.06M17.57M---
Inventory (USD)1.69B1.21B738.80M460.60M353.10M280.78M167.50M124.36M111.83M77.60M57.21M30.85M14.15M30.46M112.43M
Current Assets (USD)11.20B9.60B14.14B13.23B9.56B8.13B4.82B3.84B2.65B1.83B1.41B1.55B1.59B1.59B1.33B
Assets (USD)25.64B22.53B22.73B18.15B13.43B11.75B8.32B6.25B3.55B2.90B2.50B2.33B2.32B2.76B2.20B

News and Insights

Where Will Vertex Pharmaceuticals Be in 1 Year?

Vertex Pharmaceuticals has underperformed the broader market over the past 12 months, but the biotech company shows signs of a potential rebound. With its core cystic fibrosis franchise continuing to drive growth and several promising pipeline candidates approaching regulatory approval—including povetacicept for kidney disease, inaxaplin for APOL-1-mediated kidney disease, and zimislecel for Type 1 diabetes—the company's long-term prospects appear strong, making it a potential buying opportunity.

The Motley Fool faviconThe Motley FoolProsper Junior Bakiny
Anti-Aging Protein Research Takes a Step Forward with Cell Cloning

Avaí Bio announced a critical milestone in creating a Master Cell Bank of genetically modified cells that overexpress the α-Klotho protein, an anti-aging protein that declines by 50% after age 40. The company is partnering with Austrianova to use Cell-in-a-Box encapsulation technology for its Klothonova anti-aging and Insulinova diabetes programs. This development occurs as the cell and gene therapy market expands rapidly, with the sector forecast to grow from $10.4 billion to over $45 billion by 2035.

Benzinga faviconBenzingaEquity-Insider.Com
CRISPR Therapeutics Stock: Is It a Bargain Buy Right Now?

CRISPR Therapeutics stock has declined 9% this year following a $585.2 million convertible notes offering. While the company has an approved gene-editing therapy (Casgevy) and strong financial reserves of $1.8 billion, it remains deeply unprofitable with a net loss of $581.6 million and minimal revenue of $3.5 million. The analyst suggests it may be worth considering as a mid-cap growth stock with potential upside, though not a bargain due to inherent risks.

The Motley Fool faviconThe Motley FoolDavid Jagielski, Cpa
My Top 3 Drug Stocks for March 2026

The article recommends three pharmaceutical stocks as attractive long-term holdings: Eli Lilly, which dominates the growing chronic weight management market with its blockbuster drug tirzepatide; Vertex Pharmaceuticals, which maintains a monopoly in cystic fibrosis treatments while expanding into other therapeutic areas; and Pfizer, which despite recent underperformance, offers undervalued shares, a strong pipeline, and an attractive 6.3% dividend yield.

The Motley Fool faviconThe Motley FoolProsper Junior Bakiny
Best Growth Stock to Buy Right Now: Eli Lilly vs. Vertex Pharmaceuticals

Eli Lilly and Vertex Pharmaceuticals are both prominent drugmakers with strong track records, but Eli Lilly emerges as the better growth stock choice. Eli Lilly leads the rapidly growing weight-loss market with Zepbound and has a strong pipeline including orforglipron and retatrutide, plus newer approvals in Alzheimer's and eczema treatments. Vertex Pharmaceuticals has a solid cystic fibrosis franchise and is expanding into sickle cell disease, acute pain, and kidney disease treatments. However, Eli Lilly generates higher revenue and net income with faster growth, and both companies have similar valuations, giving Eli Lilly the edge.

The Motley Fool faviconThe Motley FoolProsper Junior Bakiny
UNCF NEW ENGLAND Raises Record-Breaking $800,000 for HBCUs and Student Success

The 2026 UNCF 'A Mind Is...' New England Gala raised a record-breaking $800,000 to support historically Black colleges and universities and provide scholarships to students. The event honored Demond Martin, Governor Charlie Baker, and Pamela Everhart for their contributions to educational equity and community development.

GlobeNewswire Inc. faviconGlobeNewswire Inc.Uncf
Is Vertex Pharmaceuticals Heading to $600?

Vertex Pharmaceuticals, a biotech leader in cystic fibrosis treatment, is expanding into new therapeutic areas with recent approvals for Casgevy (blood disorders) and Journavx (non-opioid pain). The company's kidney disease candidate povetacicept is expected to be submitted for regulatory review by month-end. With $12 billion in annual sales and non-CF drugs projected to generate $500 million this year, analysts suggest the stock trading at $480 could reach $600 (25% gain) if new drug revenues perform strongly and pipeline advancements continue.

The Motley Fool faviconThe Motley FoolAdria Cimino
Oil Crashes 10%, Stocks Rebound On Trump End-Of-War Signals: What's Moving Markets Tuesday?

U.S. stocks rallied Tuesday as crude oil plummeted 10% to $85/barrel following President Trump's signals that the Iran conflict may be ending soon and his commitment to keep the Strait of Hormuz safe. The S&P 500 rose 0.3%, Dow gained 0.4%, and Nasdaq 100 advanced 0.5%, while the VIX dropped 9.3% signaling reduced market fear.

Benzinga faviconBenzingaPiero Cingari
Vertex's New Kidney Drug Delivers Big Trial Win, Stock Jumps

Vertex Pharmaceuticals shares surged 6.32% in premarket trading after announcing positive Phase 3 RAINIER trial results for its kidney drug povetacicept. The trial met its primary objective with a 52% reduction in urine protein and 49.8% reduction versus placebo. An analyst upgraded the probability of success to 90% ahead of expected FDA approval by year-end.

Benzinga faviconBenzingaVandana Singh
2 Biotech Giants to Buy in 2026

The article recommends two biotech companies as strong portfolio additions in 2026. Regeneron Pharmaceuticals is highlighted for its blockbuster drugs Dupixent and Eylea HD showing strong sales growth, along with a rich pipeline in multiple therapeutic areas, trading at a reasonable 17x forward earnings. Vertex Pharmaceuticals is praised as the leading cystic fibrosis treatment player with strong intellectual property protection and recent expansion into gene-editing and pain management, trading at 24x forward earnings.

The Motley Fool faviconThe Motley FoolAdria Cimino