Exelixis Inc is a biopharmaceutical firm that discovers, develops, and commercializes treatments for cancer. Its molecule, cabozantinib, is indicated for the treatment of patients with metastatic medullary thyroid cancer under the name Cometriq and for the treatment of kidney and liver cancer under the name Cabometyx. Exelixis and its partner Roche have also brought Cotellic to market for the treatment of melanoma.
Company Info
SIC2836
Composite FIGIBBG000BQ4WF8
CIK0000939767
IPOApr 11, 2000
Sectorbiological products, (no diagnostic substances)
The chart shows the growth of an initial investment of $10,000 in Exelixis Inc, comparing it to the performance of the S&P 500 index. All prices have been adjusted for splits and dividends.
Returns By Period
Exelixis Inc (EXEL) has returned 0.83% so far this year and 31.53% over the past 12 months. Looking at the last ten years, EXEL has achieved an annualized return of 26.48%, outperforming the Benchmark (SPY), which averaged 12.23% per year.
EXEL
1M6.38%
6M8.91%
YTD0.83%
1Y31.53%
5Y13.69%
10Y26.48%
Benchmark (SPY)
1M-3.85%
6M-2.35%
YTD-4.36%
1Y34.06%
5Y9.80%
10Y12.23%
Monthly Returns
The table below presents the monthly returns of Exelixis Inc (EXEL) with color gradation from worst to best to easily spot seasonal factors.
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
2026
-4.96%
4.88%
2.12%
1.95%
2025
-1.16%
17.96%
-4.85%
6.44%
10.02%
1.23%
-17.85%
3.31%
10.87%
-6.37%
17.63%
-0.03%
2024
-8.92%
0.69%
7.81%
-0.47%
0.23%
4.08%
4.59%
10.72%
0.31%
27.79%
9.03%
-8.59%
2023
9.92%
-2.57%
13.64%
-5.43%
5.36%
-1.24%
3.46%
13.42%
-3.15%
-6.32%
5.67%
9.89%
2022
-0.71%
12.80%
11.02%
-2.15%
-17.47%
14.21%
0.67%
-15.32%
-11.56%
4.28%
0.65%
-6.25%
2021
10.06%
-3.73%
3.34%
8.17%
-8.63%
-19.38%
-7.77%
12.63%
9.82%
1.85%
-22.20%
8.42%
2020
-2.88%
8.27%
-7.17%
47.61%
1.48%
-3.57%
-3.43%
-4.68%
10.58%
-16.71%
-7.66%
3.35%
2019
22.25%
-4.97%
4.02%
-18.05%
-0.96%
9.03%
-2.48%
-8.40%
-10.86%
-12.96%
6.81%
5.64%
2018
-0.13%
-14.94%
-13.95%
-5.02%
-0.34%
3.26%
-2.54%
-7.98%
-4.99%
-21.73%
46.22%
-6.24%
2017
19.68%
18.10%
-0.46%
3.51%
-17.07%
31.57%
9.85%
7.46%
-17.72%
1.89%
8.54%
12.30%
2016
16.71%
40.17%
21.09%
16.94%
21.59%
14.91%
-18.48%
60.08%
-12.29%
Performance Indicators
The charts below present risk-adjusted performance metrics for Exelixis Inc (EXEL) and compare them to a Benchmark (SPY). These indicators evaluate an investment's returns against its associated risks.
Sharpe ratio
Sortino ratio
Omega ratio
Calmar ratio
Martin ratio
sharpe ratio
The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.
These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns.
The chart below shows the rolling Sharpe ratio of EXEL compared to the benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.
Volatility Chart
The current Exelixis Inc volatility is 1.48%, representing the standart deviation of percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. It shows the maximum percentage drop from a peak to a trough over a specified period, indicating the risk of significant losses. Although chart shows positive values, it represents the percentage drop from the peak, so a value of 10% means the portfolio has dropped 10% from its highest point.
Income Statement
The income statement provides a summary of a company's revenues, expenses, and profits over a specific period. It shows how much money the company earned (revenues) and how much it spent (expenses), leading to the net income or profit. This statement is crucial for understanding a company's financial performance and profitability.
2024
2023
2022
2021
2019
2018
2017
2016
2015
2013
2012
2011
Liabilities And Equity (USD)
2.95B
2.94B
3.07B
2.14B
1.89B
1.42B
655.29M
597.54M
327.96M
503.29M
721.10M
393.26M
Equity Attributable To Parent (USD)
2.24B
2.26B
2.49B
1.88B
1.69B
1.29B
284.96M
89.32M
-114.83M
66.24M
296.43M
90.63M
Equity Attributable To Noncontrolling Interest (USD)
The article recommends three healthcare stocks trading under $50: Pfizer (PFE) at $27.45 with a low forward P/E of 9x and a strong oncology pipeline; Novo Nordisk (NVO) at $38.43 positioned to capitalize on the expanding weight-loss drug market with products like Wegovy; and Exelixis (EXEL) at $41.80, a focused oncology player with the successful Cabometyx therapy and promising pipeline candidates like zanzalintinib.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Focused oncology player with growing revenue from successful Cabometyx franchise, promising pipeline candidates like zanzalintinib for colorectal cancer, and potential for label expansions before patent cliff in 2030.
Exelixis, a U.S.-based biotech company specializing in cancer treatments, is positioned for market-beating returns through its growing pipeline beyond its blockbuster cabozantinib drug. The company reported 57.9% EPS growth in 2025 and recently received FDA approval for zanzalintinib for metastatic colorectal cancer. With zanzalintinib in four phase 3 trials and strategic partnerships with major pharma companies, Exelixis aims to become a top-five solid tumor oncology company.
The Motley Fool•James Halley
AI Insight
Strong earnings growth (57.9% EPS increase in 2025), FDA approval for zanzalintinib, robust pipeline with multiple phase 3 trials, patent protection until 2031, strategic partnerships with major pharma companies, and stock up 97% over five years demonstrate solid fundamentals and growth potential.
InSilico Medicine, fresh from Hong Kong's biggest 2025 IPO raising HK$2.28 billion, announced a multi-year drug discovery partnership with French pharmaceutical company Servier worth up to $888 million. The deal leverages InSilico's AI platform for cancer drug development. Despite strong investor backing and rapid pipeline progress, the company faces profitability challenges with volatile revenue heavily dependent on partnership payments.
Benzinga•Bamboo Works
AI Insight
Has existing licensing deal with InSilico with combined potential value approaching $2 billion, but no new developments or changes mentioned in this article.
The Motley Fool recommends two biotech stocks for long-term investment: Axsome Therapeutics, which has generated strong revenue growth (65.8% YoY through Q3 2025) with approved products and promising late-stage candidates including Auvelity for Alzheimer's disease agitation; and Exelixis, an oncology specialist with its blockbuster drug Cabometyx and an upcoming next-generation cancer medicine Zanzalintinib in phase 3 trials for metastatic colorectal cancer.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Steady revenue growth of 7.5% YoY through Q3 2025, dominant market position in renal cell carcinoma with Cabometyx, strong patent protection until next decade, and promising phase 3 results for next-generation cancer drug Zanzalintinib addressing high unmet need in metastatic colorectal cancer.
The article highlights two biotechnology companies, Therapeutics and Exelixis, as promising investment opportunities for 2026 due to their innovative drug pipelines and potential for significant market growth.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Successful cancer medicine Cabometyx, 10.8% revenue growth, legal protection against generic competition until 2030, developing new cancer treatments like zanzalintinib with promising clinical trial results
Adagene initiated a Phase 2 clinical trial for muzastotug (ADG126) in combination with KEYTRUDA for microsatellite stable colorectal cancer, randomizing patients to 10 or 20 mg/kg doses with anticipated trial completion in early 2027.
GlobeNewswire Inc.•Adagene Inc.
AI Insight
Mentioned in collaboration agreement but no specific details provided in main article
Merck and Eisai reported positive Phase 3 trial results for their cancer therapy combination Welireg and Lenvima in treating advanced renal cell carcinoma, demonstrating significant improvement in progression-free survival compared to rival treatments.
Benzinga•Vandana Singh
AI Insight
Their drug Cabometyx was outperformed by Merck's combination therapy in clinical trials
Exelixis is a biotech company with a strong market position in cancer drugs, particularly kidney cancer treatment Cabometyx. The company is profitable, has promising drug candidates like zanzalintinib, and is well-positioned for future growth in oncology.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Strong market position in kidney cancer treatment, profitable, promising drug pipeline, legal protection for Cabometyx until 2030, and potential for future growth
The pancreatic endocrine tumor market is expected to grow significantly between 2025-2034, driven by novel therapies like Zanzalintinib, RYZ101, and Nab-sirolimus, which could transform treatment approaches for this rare cancer.
GlobeNewswire Inc.•Delveinsight
AI Insight
Developing Zanzalintinib, a promising experimental tyrosine kinase inhibitor in Phase II/III trials for pancreatic neuroendocrine tumors
Two biotech companies, Axsome Therapeutics and Exelixis, are predicted to potentially outperform the market in the next five years due to strong product portfolios, promising drug pipelines, and potential for significant market expansion in healthcare treatments.
The Motley Fool•Prosper Junior Bakiny
AI Insight
Successful cancer treatment Cabometyx, protected from generic competition until 2030, promising new drug candidate zanzalintinib in colorectal cancer, and continued focus on high unmet medical needs